Granulosa Cell Tumor
Granulosa Cell Tumor (GCT) is a rare type of cancer that starts in the ovaries, specifically from cells called granulosa cells. These cells are naturally involved in producing hormones and helping eggs develop. Unlike many other ovarian cancers, GCTs are often slow-growing and typically have a favorable outlook, especially when detected early. A key feature of these tumors is their ability to produce hormones, mainly estrogen, which can lead to various symptoms. The exact reason why a GCT develops is often unknown. It's not usually something that runs in families. Researchers believe these tumors form due to specific genetic changes or mutations within the granulosa cells themselves, causing them to grow uncontrollably. GCTs can occur at any age, but they are most commonly found in women after menopause. Your lab tests are essential for both diagnosing and managing Granulosa Cell Tumors. Certain markers, like specific hormone levels (e.g., estrogen or inhibin A/B), can be elevated when a GCT is present. These blood tests, alongside imaging scans, help doctors confirm a diagnosis. They are also vital for monitoring how well treatment is working and for keeping an eye out for any signs that the tumor might have returned after treatment.
Common Symptoms
- Abnormal vaginal bleeding (such as postmenopausal bleeding, irregular periods, or heavy periods)
- Abdominal pain or discomfort
- Abdominal swelling or bloating
- Breast tenderness or enlargement
- Early signs of puberty in young girls (like breast development or periods starting too soon)
Clinical Sources
- Granulosa Cell Tumor: Causes & TreatmentCleveland Clinic
Diagnostic Lab Tests
Tests commonly used to diagnose or monitor Granulosa Cell Tumor:
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