Hereditary Angioedema
Hereditary Angioedema (HAE) is a rare genetic condition that causes recurrent, unpredictable episodes of severe swelling, also known as angioedema. Unlike common allergic reactions, HAE swelling is typically not itchy, does not involve hives, and does not respond to standard allergy medications like antihistamines or corticosteroids. The swelling can affect various parts of the body, including the skin (e.g., hands, feet, face, genitals), the lining of the gastrointestinal tract, and most critically, the airways.
Common Symptoms
- Recurrent, localized swelling of the skin (e.g., hands, feet, face, genitals)
- Severe abdominal pain, often accompanied by nausea, vomiting, or diarrhea
- Potentially life-threatening swelling of the throat or airway
- Swelling that is typically non-itchy and does not present with hives
- A tingling sensation, fatigue, or mild skin rash (erythema marginatum) that may precede an attack
Clinical Sources
- Hereditary angioedema: MedlinePlus GeneticsMedlinePlus
- Hereditary Angioedema (HAE) Symptoms, Causes & TreatmentCleveland Clinic
- Angioedema: Causes, Symptoms, Types & TreatmentsCleveland Clinic
Diagnostic Lab Tests
Tests commonly used to diagnose or monitor Hereditary Angioedema:
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