Albumin/Globulin (A/G) Ratio
- Sample Type
- Standard
- Fasting
- No
- Unit
- Ratio
The A/G ratio is a calculated value derived from a Serum Protein Electrophoresis or Liver Function Test. Albumin is produced by the liver and maintains osmotic pressure, while globulins include enzymes, transport proteins, and antibodies (gamma globulins). A shift in this ratio is often the first sign of liver disease (where albumin production drops) or plasma cell dyscrasias like Multiple Myeloma (where globulin production spikes).
Why Context Matters
The ratio can be misleading if both albumin and globulin are abnormally high or low simultaneously (e.g., in severe dehydration or panhypoproteinemia), resulting in a 'normal' ratio despite underlying pathology.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Albumin/Globulin (A/G) Ratio:
Official Sources
- Multiple Myeloma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology - PubMedpubmed.ncbi.nlm.nih.gov
- NCCN Guidelines® Insights: Multiple Myeloma, Version 1.2025 - PubMedpubmed.ncbi.nlm.nih.gov
Research & Guidelines
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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