Anti Cardiolipin AB-Profile
- Sample Type
- Serum
- Fasting
- No
- Unit
- GPL/MPL
Function
Anti-cardiolipin antibodies are autoantibodies directed against cardiolipin, a phospholipid found in the inner mitochondrial membrane. These antibodies interfere with the normal function of vascular cells and blood clotting factors, shifting the body toward a pro-thrombotic (clot-forming) state.
Why it is Ordered
This profile is a core component in diagnosing Antiphospholipid Syndrome (APS). It is typically ordered for patients who experience unexplained blood clots (Deep Vein Thrombosis or Stroke), or for women with a history of recurrent miscarriages or pregnancy complications like pre-eclampsia. It is also used to evaluate patients with Systemic Lupus Erythematosus (SLE), as these antibodies frequently co-occur.
Associated Conditions
- Antiphospholipid Syndrome (APS): Characterized by thrombosis and pregnancy loss.
- Systemic Lupus Erythematosus (SLE): About 30-40% of SLE patients have these antibodies.
- Recurrent Pregnancy Loss: Related to placental vascular issues caused by the antibodies.
- Thrombocytopenia: Low platelet counts are often associated with the presence of these antibodies.
Panel Components
This test is a profile comprising the following specific markers:
Why Context Matters
Anti-cardiolipin antibodies can be transiently elevated due to acute infections (like syphilis, malaria, or even COVID-19) or the use of certain medications (like phenothiazines). To diagnose APS, the test MUST be positive on two separate occasions at least 12 weeks apart. A single high result is not diagnostic of a chronic autoimmune condition and requires a second opinion and re-testing to ensure it wasn't a temporary reaction to an infection.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Anti Cardiolipin AB-Profile:
Official Sources
- Diagnosis and management of antiphospholipid syndrome - PMCpmc.ncbi.nlm.nih.gov
Research & Guidelines
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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