Aspartate Aminotransferase (AST)
- Sample Type
- Standard
- Fasting
- No
- Unit
- U/L
Aspartate Aminotransferase (AST), formerly known as SGOT, is an enzyme present in metabolically active tissues, including the liver, myocardium, skeletal muscle, kidneys, and brain. In the context of a Liver Function Test (LFT), it serves as a sensitive marker for hepatocellular injury. When hepatocytes are damaged or die, AST leaks into the bloodstream. While less specific to the liver than ALT (Alanine Aminotransferase), the AST/ALT ratio (De Ritis ratio) is clinically significant; an AST level significantly higher than ALT (ratio >2:1) is often suggestive of alcoholic liver disease or advanced cirrhosis.
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Why Context Matters
AST is not liver-specific. Elevations can be caused by strenuous exercise, intramuscular injections, myocardial infarction, or hemolytic anemia. A second opinion or follow-up is necessary to differentiate between hepatic origin and muscle/cardiac sources.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Aspartate Aminotransferase (AST):
Official Sources
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Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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