Basophils
- Sample Type
- Standard
- Fasting
- No
- Unit
- %
Basophils are the least common granulocyte in the peripheral blood. They play a pivotal role in the immediate hypersensitivity response by releasing histamine, heparin, and proteolytic enzymes via IgE-mediated degranulation. In a differential count, a persistent elevation (basophilia) is a sensitive marker for myeloproliferative neoplasms, particularly Chronic Myeloid Leukemia (CML), or systemic mastocytosis. They also increase in chronic inflammation and certain endocrinopathies like hypothyroidism.
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Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Because basophils exist in very low percentages (often <1%), automated hematology analyzers can occasionally misidentify small lymphocytes or degranulated neutrophils as basophils. A manual peripheral smear review is often necessary to confirm true basophilia, especially if the count is over 2%.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Basophils:
Official Sources
- Blood Differential: MedlinePlus Medical TestMedlinePlus
Research & Guidelines
- PubMed: Basophils Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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