Casts
- Sample Type
- Standard
- Fasting
- No
- Unit
- /lpf
Casts are cylindrical structures formed in the distal convoluted tubule and collecting ducts of the kidney. Their presence in urine sediment (Complete Urine Examination) provides a 'mold' of the nephron. While hyaline casts can be normal after exercise, cellular casts (RBC, WBC, Granular, Waxy) are hallmark indicators of renal parenchymal disease, such as glomerulonephritis or acute tubular necrosis.
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Why Context Matters
Casts are unstable and disintegrate rapidly in alkaline urine (pH > 7.0) or dilute urine (Specific Gravity < 1.010). A 'negative' result might be a false negative if the sample was not fresh or the patient was overly hydrated. Conversely, strenuous exercise can cause transient hyaline or even granular casts in healthy individuals.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Casts:
Official Sources
Research & Guidelines
- PubMed: Casts Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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