Galactomannan Antigen for Aspergillus

Function

Galactomannan is a polysaccharide component found in the cell walls of most Aspergillus species. As the fungus grows in host tissue, this antigen is released into the bloodstream or other body fluids. The Galactomannan Antigen test is a non-invasive immunoassay designed to detect this specific molecule, facilitating the early diagnosis of Invasive Aspergillosis (IA), a severe and often fatal fungal infection.

Why it is Ordered

This test is a critical component of the diagnostic workup for immunocompromised patients, including:

• Stem Cell/Organ Transplant Recipients: Who are at the highest risk for invasive fungal infections.
• Leukemia Patients: Particularly those experiencing prolonged periods of neutropenia (low white blood cell counts).
• Early Detection: Because clinical symptoms of fungal pneumonia are non-specific, detecting galactomannan can allow for earlier initiation of antifungal therapy before imaging shows definitive signs.
• Monitoring: To track the efficacy of antifungal medications.

Associated Conditions

• Invasive Aspergillosis (IA): The primary condition detected, usually involving the lungs but potentially spreading to the brain or other organs.
• Chronic Pulmonary Aspergillosis: Though the test is less sensitive for the chronic form compared to the invasive form.