Leukocyte Esterase
- Sample Type
- Standard
- Fasting
- No
- Unit
- n/a
Leukocyte Esterase is an enzyme produced by white blood cells (neutrophils). Its presence in urine, detected during a Complete Urine Examination, is a primary indicator of pyuria (white cells in the urine). This is most commonly associated with a Urinary Tract Infection (UTI), though it can also indicate non-infectious inflammation of the kidneys or bladder (e.g., interstitial cystitis, nephrolithiasis). In the context of a urinalysis panel, it is evaluated alongside Nitrites and microscopic WBC counts to confirm infection.
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Why Context Matters
False positives can occur due to vaginal contamination (secretions), high protein levels, or certain drugs like nitrofurantoin. False negatives may result from high glucose, high specific gravity, or high doses of Vitamin C (ascorbic acid) which interfere with the chemical reaction on the dipstick.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Leukocyte Esterase:
Official Sources
- Urinalysis - Mayo ClinicMayo Clinic
Research & Guidelines
- PubMed: Leukocyte Esterase Clinical GuidelinesNCBI / PubMed
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Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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