EndocrinologyEndocrinology

LH, FSH Panel

Normal Range
Varies by cycle phase; LH: 2-13 mIU/mL, FSH: 3-10 mIU/mL (Follicular)
Sample Type
Serum
Fasting
No
Unit
mIU/mL

Function

Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) are gonadotropins produced by the anterior pituitary gland. In women, FSH stimulates the growth of ovarian follicles, while LH triggers ovulation. In men, FSH stimulates sperm production (spermatogenesis), and LH stimulates the production of testosterone by the Leydig cells in the testes.

Why it is Ordered

This panel is standard for evaluating infertility, irregular menstrual cycles, or symptoms of menopause in women. In men, it is used to investigate low testosterone, low sperm count, or decreased libido. It is also used to diagnose pituitary disorders or premature/delayed puberty in adolescents.

Associated Conditions

  • Polycystic Ovary Syndrome (PCOS): Often characterized by an elevated LH to FSH ratio (e.g., 2:1 or 3:1).
  • Menopause/Premature Ovarian Failure: Marked by significantly elevated FSH levels as the pituitary tries to stimulate unresponsive ovaries.
  • Hypogonadotropic Hypogonadism: Low levels of both LH and FSH, suggesting a problem with the hypothalamus or pituitary gland.
  • Testicular Failure: High LH and FSH in men with low testosterone indicates the problem is within the testes themselves.

Panel Components

This test is a profile comprising the following specific markers:

Follicle Stimulating Hormone (FSH)
mIU/mL
Luteinizing Hormone (LH)
mIU/mL

Why Context Matters

LH and FSH are released in pulses and levels fluctuate significantly throughout the menstrual cycle. Testing on the wrong day of the cycle (ideally Day 2-5 for baseline) can lead to misinterpretation. Additionally, biotin supplements, hormonal contraceptives, and high stress levels can alter results. A second opinion ensures the clinical context of the cycle or timing is correctly mapped to the data.

Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.

Clinical References

Source-of-truth databases and clinical guidelines for LH, FSH Panel:

Research & Guidelines

Related Indicators

Thyroid Function Panel (Free T3, Free T4, TSH)

View Range

24-Hour Urinary VMA

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17-Alpha Hydroxy Progesterone

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DR

Medically Reviewed by Dr. Binoy Babu, MBBS

Board Certified Doctor • 10+ Years Clinical Experience

Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.

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