Plasma Renin Activity
- Sample Type
- Standard
- Fasting
- No
- Unit
- ng/mL/hr
Plasma Renin Activity (PRA) measures the rate of formation of Angiotensin I from Angiotensinogen, reflecting the functional activity of the renin enzyme. It is a cornerstone in the evaluation of the Renin-Angiotensin-Aldosterone System (RAAS). In clinical practice, it is primarily used to differentiate between primary and secondary hyperaldosteronism. When interpreted alongside plasma aldosterone levels (the Aldosterone-Renin Ratio or ARR), it helps diagnose Primary Aldosteronism (Conn's Syndrome), a potentially curable cause of hypertension.
Check Your Result
Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
PRA is highly sensitive to external factors. Results are significantly altered by the patient's posture (upright vs. supine), sodium intake, and the use of common antihypertensives like beta-blockers, ACE inhibitors, and diuretics. A second opinion ensures that the pre-test conditions (e.g., salt loading or medication washout) were strictly followed.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Plasma Renin Activity:
Official Sources
- Renin Test: MedlinePlus Medical TestMedlinePlus
- Aldosterone and Renin Test - Testing.comTesting.com
Research & Guidelines
- PubMed: Plasma Renin Activity Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
Get Notified When Dr. Babu Is Available