Serum Ceruloplasmin
- Sample Type
- Serum
- Fasting
- No
- Unit
- mg/dL
Function
Ceruloplasmin is a ferroxidase enzyme that carries about 95% of the copper in the plasma. It is produced in the liver. Its primary role is to convert ferrous iron (Fe2+) to ferric iron (Fe3+), allowing iron to bind to transferrin for transport. It also plays a vital role in regulating copper metabolism.
Why it is Ordered
This test is primarily used as a screening tool for Wilson's Disease, a rare genetic disorder where copper accumulates in the liver, brain, and other vital organs. It may also be ordered for patients showing symptoms of copper deficiency or in the evaluation of unexplained liver disease or neurological symptoms (like tremors or psychiatric changes).
Associated Conditions
- Wilson's Disease: Characterized by very low levels of ceruloplasmin.
- Menkes Syndrome: A genetic disorder of copper absorption (low levels).
- Liver Failure: Since the protein is made in the liver, advanced cirrhosis can lower levels.
- Inflammatory States: Ceruloplasmin is an 'acute phase reactant,' meaning levels rise during infection, pregnancy, or trauma.
Check Your Result
Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Ceruloplasmin levels can be misleading because they rise during inflammation or with estrogen use (birth control, pregnancy). Therefore, a person with Wilson's disease who also has an active infection might show a 'falsely normal' ceruloplasmin level. A second opinion involving a 24-hour urine copper test or a liver biopsy is often necessary for a definitive diagnosis.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Serum Ceruloplasmin:
Official Sources
- EASL-ERN Clinical Practice Guidelines on Wilson's disease - PubMedpubmed.ncbi.nlm.nih.gov
- Wilson disease: a summary of the updated AASLD Practice Guidance - PMCpmc.ncbi.nlm.nih.gov
- EASL Clinical Practice Guidelines: Wilson's disease - PubMedpubmed.ncbi.nlm.nih.gov
Research & Guidelines
- PubMed: Serum Ceruloplasmin Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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