Serum Ferritin

Function

Ferritin is a blood protein that contains iron. It is the primary way your body stores iron for future use. The amount of ferritin in the blood (serum ferritin) is directly proportional to the total amount of iron stored in your body. It acts as a buffer against iron deficiency and iron overload.

Why it is Ordered

This test is fundamental for assessing iron status. It is ordered to:

• Diagnose Anemia: Specifically to distinguish iron deficiency anemia from other types.
• Monitor Iron Overload: In conditions like hemochromatosis.
• Inflammation Marker: Since it is an acute-phase reactant, it rises during inflammation or infection.
• Assess Nutritional Status: Especially in vegetarians, pregnant women, or those with malabsorption issues.

Associated Conditions

• Iron Deficiency Anemia: Characterized by very low ferritin.
• Hemochromatosis: A genetic disorder causing excessive iron absorption.
• Chronic Kidney Disease: Often involves complex iron management.
• Liver Disease: As ferritin is stored in the liver, damage can release it into the blood.
• Still's Disease: Often presents with extremely high (thousands) ferritin levels.

Understanding ferritin levels is essential for determining if a patient requires iron supplementation or, conversely, iron removal (phlebotomy).