Serum Transferrin
- Sample Type
- Serum
- Fasting
- Required
- Unit
- mg/dL
Function
Transferrin is the main protein in the blood that binds to iron and transports it throughout the body. It is synthesized in the liver. By measuring transferrin, clinicians can assess the body's iron-carrying capacity. It is inversely related to iron stores; when iron stores are low, the liver produces more transferrin to maximize iron transport.
Why it is Ordered
It is ordered as part of an iron panel (including Ferritin and TIBC) to evaluate suspected iron deficiency anemia, iron overload (hemochromatosis), or to monitor nutritional status. It is a 'negative acute-phase reactant,' meaning its levels drop during inflammation or chronic disease.
Associated Conditions
- Iron Deficiency Anemia: High transferrin, low iron.
- Hemochromatosis: Low transferrin due to iron saturation.
- Liver Disease: Decreased production of the protein.
- Protein-Energy Malnutrition: Reduced synthesis due to lack of amino acids.
Check Your Result
Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Transferrin levels are heavily influenced by hormonal changes and protein status. Estrogen therapy or pregnancy can artificially increase transferrin levels, while chronic inflammation or infection can cause levels to drop (as it is a negative acute-phase reactant). If a patient is acutely ill, transferrin may not accurately reflect iron stores.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Serum Transferrin:
Official Sources
- Transferrin ReceptorMedscape
Research & Guidelines
- PubMed: Serum Transferrin Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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