STIL-TAL1 Fusion (SIL-TAL1)
- Sample Type
- Standard
- Fasting
- No
- Unit
- Qualitative
The STIL-TAL1 fusion (previously known as SIL-TAL1) results from a submicroscopic interstitial deletion on chromosome 1p32. This genetic rearrangement is found in approximately 10-25% of pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) cases. It leads to the ectopic expression of the TAL1 transcription factor under the control of the STIL promoter, driving leukemogenesis. Detecting this fusion is crucial for the molecular subtyping of T-ALL, prognostic stratification, and monitoring Minimal Residual Disease (MRD) following chemotherapy or stem cell transplantation.
Why Context Matters
Technical sensitivity varies between RT-PCR and FISH methodologies. Interpretation can be confounded by low blast percentages in the sample or clonal evolution during treatment. A second opinion ensures the fusion transcript variant is correctly identified and correlated with the overall clinical picture of leukemia.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for STIL-TAL1 Fusion (SIL-TAL1):
Official Sources
Research & Guidelines
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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