Addison's Disease (Adrenal Insufficiency)
Addison's disease is a disorder that occurs when your body produces insufficient amounts of certain hormones by your adrenal glands, specifically cortisol and often aldosterone. It can lead to various symptoms including fatigue and weight loss.
Common Symptoms
- Fatigue
- Weight loss
- Darkening of skin (hyperpigmentation)
- Low blood pressure
- Salt craving
Clinical Sources
- Addison's Disease: What It Is, Causes, Symptoms & TreatmentCleveland Clinic
Diagnostic Lab Tests
Tests commonly used to diagnose or monitor Addison's Disease (Adrenal Insufficiency):
Urine Sodium
Sodium is the primary extracellular electrolyte responsible for maintaining osmotic pressu...
Serum Cortisol
Cortisol is often referred to as the 'stress hormone' and is a vital steroid hormone produ...
Urine Potassium
Potassium is a vital electrolyte essential for nerve conduction, muscle contraction, and m...
Aldosterone-Renin Ratio
The Aldosterone-Renin Ratio (ARR) is the most reliable screening test for Primary Aldoster...
Aldosterone
Aldosterone is a steroid hormone produced by the adrenal cortex. Its primary function is t...
Plasma Renin Activity
Plasma Renin Activity (PRA) measures the capacity of the enzyme renin to generate angioten...
Angiotensin Converting Enzyme
Angiotensin-Converting Enzyme (ACE) is a critical enzyme primarily produced by epithelial ...
Sodium
Sodium is the primary extracellular cation and is essential for maintaining osmotic pressu...
Plasma Renin Activity
Plasma Renin Activity (PRA) measures the rate of formation of Angiotensin I from Angiotens...
Plasma Aldosterone
Aldosterone is a mineralocorticoid hormone produced by the adrenal cortex that regulates s...
Urine For Spot Sodium
Sodium is a critical electrolyte that regulates the amount of water in the body and plays ...
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