Primary Biliary Cholangitis (PBC)
PBC is a chronic autoimmune disease that slowly destroys the small bile ducts in the liver. Bile, a digestive fluid, builds up in the liver, leading to scarring and eventually cirrhosis.
Common Symptoms
- Fatigue
- Itchy skin
- Dry eyes and mouth
- Jaundice
- Abdominal pain
Clinical Sources
- Primary Biliary Cholangitis: What It Is, Symptoms, TreatmentCleveland Clinic
Diagnostic Lab Tests
Tests commonly used to diagnose or monitor Primary Biliary Cholangitis (PBC):
Direct Bilirubin
Direct (conjugated) bilirubin measures the portion of bilirubin that has been processed by...
Bile Pigments (Urinary Bilirubin)
Bilirubin should not be detectable in the urine of a healthy individual. Because only conj...
Urobilinogen
Urobilinogen is a colorless byproduct of bilirubin reduction by intestinal bacteria. Most ...
Urobilinogen
Urobilinogen is a byproduct of bilirubin reduction by intestinal bacteria. Most is excrete...
Total Bilirubin
Bilirubin is a yellowish pigment formed during the normal breakdown of red blood cells (he...
Ascitic Fluid Bilirubin
Measuring bilirubin in ascitic fluid is a specialized test used to diagnose biliary perfor...
Smooth Muscle Antibody (ASMA)
ASMA is an autoantibody directed against the cytoskeleton of smooth muscle cells (primaril...
Liver Function Test Without GGT
The Liver Function Test (LFT) without GGT is a panel of blood tests used to evaluate the h...
Bilirubin
Bilirubin in the urine (bilirubinuria) is always considered an abnormal finding. Only conj...
Complete Urine Examination
The Complete Urine Examination (CUE), also known as Urinalysis, is a fundamental diagnosti...
Urobilinogen - Urine
Urobilinogen is a colorless byproduct of bilirubin reduction. It is formed in the intestin...
Alkaline Phosphatase (ALP)
Alkaline Phosphatase (ALP) is a hydrolase enzyme found primarily in the liver (lining of t...
HCV (Tridot)
The HCV (Tridot) test is a rapid visual antigen-antibody immunoassay used for the qualitat...
Hepatitis B Surface Antigen (HBsAg)
The Hepatitis B Surface Antigen (HBsAg) test is the earliest immunological marker of an ac...
Bile Salts & Pigments - Urine
This test detects the presence of bile salts and bile pigments (specifically conjugated bi...
Urine Routine
A routine urinalysis (Urine Routine) is a fundamental diagnostic tool used to assess the c...
Bilirubin (Total And Direct)
Bilirubin is a yellowish pigment made during the normal breakdown of red blood cells (hemo...
Urobilinogen
Urobilinogen is a byproduct of bilirubin reduction by intestinal bacteria. In a Complete U...
Bilirubin (Urine)
Under normal physiological conditions, bilirubin (specifically conjugated bilirubin) is no...
Serum Haptoglobulin
Haptoglobin is a protein produced by the liver that functions as a scavenger for free hemo...
H.C.V. ELISA
The HCV ELISA (Enzyme-Linked Immunosorbent Assay) is a screening test used to detect antib...
Gamma-Glutamyl Transferase (GGT)
Gamma-Glutamyl Transferase (GGT) is an enzyme found in high concentrations in the liver, b...
Anti HAV Antibodies
The Anti-HAV (Hepatitis A Virus) antibody test detects the presence of antibodies produced...
Stool Color
Stool color is a primary physical observation in a Complete Stool Examination. It provides...
Anti Mitochondrial Antibody (ELISA)
The Anti-Mitochondrial Antibody (AMA) test is a serological marker primarily used to detec...
Total Bilirubin
Total Bilirubin is a measurement of the sum of conjugated (direct) and unconjugated (indir...
Urine Color
The color of urine is a primary physical characteristic evaluated during a Urine Routine e...
Total Bilirubin
Total Bilirubin measures the sum of conjugated (direct) and unconjugated (indirect) biliru...
Liver-Kidney Microsome (LKM)-1 Antibody (ELISA)
The Liver-Kidney Microsome Type 1 (LKM-1) antibody test is a specialized immunological ass...
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