Anti-dsDNA
- Sample Type
- Standard
- Fasting
- No
- Unit
- IU/mL
Anti-dsDNA antibodies are a subset of Antinuclear Antibodies (ANA) that specifically target the double-stranded DNA within cell nuclei. This test is a hallmark for diagnosing Systemic Lupus Erythematosus (SLE), as it is highly specific (approximately 95-100%). Within an ENA or ANA profile, it serves as a critical confirmatory marker. Furthermore, levels often fluctuate with disease activity; a rise in titer frequently precedes a clinical 'flare,' particularly Lupus Nephritis (kidney involvement), making it vital for monitoring treatment efficacy.
Check Your Result
Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Titer levels can vary significantly between different assay methodologies (e.g., ELISA vs. CIA vs. Farr assay). Additionally, some patients may exhibit clinical symptoms of SLE while remaining anti-dsDNA negative, or have 'low-positive' results that are non-specific and found in other autoimmune conditions like autoimmune hepatitis.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Anti-dsDNA:
Official Sources
- Anti-dsDNA Test - Testing.comTesting.com
- Elevated ssdna | Mayo Clinic ConnectMayo Clinic Connect
- Histone Antibody - Understand the TestTesting.com
Research & Guidelines
- PubMed: Anti-dsDNA Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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