Anti-Jo-1 Antibody
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- Standard
- Fasting
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The Anti-Jo-1 antibody targets histidyl-tRNA synthetase and is a hallmark marker within the ANA Profile (ENA Panel). It is specifically associated with Anti-Synthetase Syndrome, a subset of idiopathic inflammatory myopathies (IIM). Its presence is strongly predictive of polymyositis or dermatomyositis, often accompanied by interstitial lung disease (ILD), Raynaud's phenomenon, and 'mechanic's hands'. Screening for this is vital when a patient presents with unexplained proximal muscle weakness and pulmonary symptoms.
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Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
While highly specific for anti-synthetase syndrome, a negative Jo-1 does not rule out inflammatory myopathy, as several other anti-synthetase antibodies (like PL-7 or PL-12) exist but aren't always included in standard screens. Furthermore, false positives can occur in rare cases of chronic viral infections, requiring clinical correlation with muscle biopsy or EMG.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Anti-Jo-1 Antibody:
Official Sources
- New Criteria Needed for Antisynthetase Syndrome - PubMedpubmed.ncbi.nlm.nih.gov
Research & Guidelines
- PubMed: Anti-Jo-1 Antibody Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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