Anti-Scl-70
- Sample Type
- Standard
- Fasting
- No
- Unit
- Index
Anti-Scl-70 (anti-topoisomerase I) is an autoantibody found in the serum of patients with Systemic Sclerosis (Scleroderma). It is highly specific for the diffuse cutaneous form of the disease. In an ANA/ENA profile, the presence of Scl-70 is a critical marker for diagnosing scleroderma and is also associated with an increased risk of developing interstitial lung disease (pulmonary fibrosis).
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Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
While highly specific, its sensitivity is only about 20-30%. A negative result does not rule out Scleroderma. Furthermore, different laboratory methods (ELISA vs. Multiplex) may yield varying index values near the cutoff point.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Anti-Scl-70:
Official Sources
- Scl-70 test: Confused about the results | Mayo Clinic ConnectMayo Clinic Connect
Research & Guidelines
- PubMed: Anti-Scl-70 Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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