Anti-Sm (Smith) Antibody
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Anti-Sm is an autoantibody directed against core proteins of small nuclear ribonucleoproteins (snRNPs). It is considered highly specific (nearly 99%) for Systemic Lupus Erythematosus (SLE). Within an ANA Profile, its presence is a major ACR classification criterion for Lupus, even though it is only present in about 15-30% of SLE patients.
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Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
While highly specific, the test has low sensitivity. A negative result does not rule out Lupus. Results can also vary between different assay methods (ELISA vs. Multiplex).
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Anti-Sm (Smith) Antibody:
Official Sources
- Systemic lupus erythematosus: one year in review 2025 - PubMedpubmed.ncbi.nlm.nih.gov
Research & Guidelines
- PubMed: Anti-Sm (Smith) Antibody Clinical GuidelinesNCBI / PubMed
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Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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