Hemoglobin A2
- Sample Type
- Standard
- Fasting
- No
- Unit
- %
Hemoglobin A2 (HbA2) is a minor component of adult hemoglobin. Measuring its percentage via HPLC is the gold standard for diagnosing Beta-Thalassemia trait (Minor). In patients with Beta-Thalassemia trait, the production of beta-globin chains is reduced, leading to a compensatory increase in the delta-globin chains that form HbA2. It is essential for genetic counseling and distinguishing thalassemia from simple iron deficiency anemia.
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Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
HbA2 levels can be falsely lowered by co-existing iron deficiency, which might mask a Beta-Thalassemia trait. Conversely, certain conditions like hyperthyroidism or Megaloblastic anemia can slightly elevate HbA2, leading to potential misdiagnosis.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Hemoglobin A2:
Official Sources
- Hemoglobinopathy Evaluation - Testing.comTesting.com
- Hemoglobin Test: MedlinePlus Medical TestMedlinePlus
Research & Guidelines
- PubMed: Hemoglobin A2 Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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