Hemoglobin A2
- Sample Type
- Standard
- Fasting
- No
- Unit
- %
Hemoglobin A2 (HbA2) is a minor variant of adult hemoglobin (composed of two alpha and two delta chains). In Hemoglobin Electrophoresis, its quantification is the gold standard for screening and diagnosing Beta-thalassemia trait (minor). Because Beta-thalassemia involves a reduction in beta-chain synthesis, the body compensates by producing more delta chains, leading to a characteristic rise in HbA2.
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Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Concurrent iron deficiency anemia can lower HbA2 levels, potentially bringing a high level back into the 'normal' range and masking a Beta-thalassemia diagnosis. Specialist review is needed to correlate iron studies with HbA2 results.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Hemoglobin A2:
Official Sources
- TIF Guidelines for the Management of Transfusion‐Dependent β‐Thalassemia - PMCpmc.ncbi.nlm.nih.gov
Research & Guidelines
- PubMed: Hemoglobin A2 Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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