Hemoglobin S (HbS)
- Sample Type
- Standard
- Fasting
- No
- Unit
- %
Hemoglobin S is an abnormal variant of hemoglobin that causes red blood cells to become sickle-shaped under low oxygen conditions. In Hemoglobin Electrophoresis by HPLC, measuring the percentage of HbS is the definitive method to diagnose Sickle Cell Trait (HbAS) or Sickle Cell Disease (HbSS). It helps in assessing the severity of the disease and monitoring the effectiveness of exchange transfusions.
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Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Recent blood transfusions (within the last 3-4 months) will introduce normal HbA and dilute the HbS percentage, leading to a false low reading. Certain co-inherited traits like Alpha-Thalassemia can also alter the expected percentages.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Hemoglobin S (HbS):
Official Sources
- Hemoglobin Test: MedlinePlus Medical TestMedlinePlus
- Hemoglobin test - Mayo ClinicMayo Clinic
Research & Guidelines
- PubMed: Hemoglobin S (HbS) Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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