Procalcitonin (PCT)
- Sample Type
- Standard
- Fasting
- No
- Unit
- ng/mL
Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin. In healthy individuals, it is produced by thyroid C-cells, but in response to bacterial endotoxins and inflammatory cytokines, it is produced by nearly all tissues. Within a COVID Panel, PCT serves as a critical biomarker to differentiate between viral pneumonia and secondary bacterial co-infection. While viral infections (like COVID-19) typically suppress PCT levels, an elevated level often indicates a bacterial complication, guiding clinicians in the judicious use of antibiotics and assessing the risk of progression to sepsis.
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Why Context Matters
PCT levels can be falsely elevated in cases of severe trauma, major surgery, extensive burns, or end-stage renal disease (due to reduced clearance). Conversely, localized bacterial infections may not trigger a systemic PCT rise, potentially leading to a false-negative interpretation of bacterial involvement.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Procalcitonin (PCT):
Official Sources
Research & Guidelines
- PubMed: Procalcitonin (PCT) Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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