Total Lymphocyte Count
- Sample Type
- Standard
- Fasting
- No
- Unit
- cells/µL
The Total Lymphocyte Count (TLC) measures the absolute number of lymphocytes (T-cells, B-cells, and Natural Killer cells) per microliter of blood. Within the context of a CD4 & CD8 Count panel, TLC is critical because absolute CD4/CD8 counts are often derived from the TLC and the percentage of specific T-cell subsets. It serves as a surrogate marker for immune competence, particularly in resource-limited settings for monitoring HIV progression or response to antiretroviral therapy (ART). Persistent lymphopenia is a significant predictor of opportunistic infections and mortality in immunocompromised patients.
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Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
TLC can be transiently affected by acute physical stress, corticosteroid use, or recent viral infections (other than HIV), leading to a misinterpretation of long-term immune status. Furthermore, absolute counts can fluctuate based on diurnal variation.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Total Lymphocyte Count:
Official Sources
Research & Guidelines
- PubMed: Total Lymphocyte Count Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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