Albumin (SPEP)
- Sample Type
- Standard
- Fasting
- No
- Unit
- g/dL
In Serum Protein Electrophoresis (SPEP), albumin represents the largest and fastest-moving peak. It is synthesized by the liver and maintains oncotic pressure and transport of molecules. In this specific panel, it serves as an internal reference point to quantify other globulin fractions and to screen for liver disease, malnutrition, or protein-losing conditions. A decrease in the albumin peak often accompanies a 'polyclonal' increase in gamma globulins during chronic inflammation.
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Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Albumin is a 'negative acute-phase reactant.' During any acute infection or inflammation, the liver downregulates albumin production to prioritize other proteins. Therefore, a low albumin on SPEP might reflect temporary inflammation rather than permanent liver damage or poor nutrition.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Albumin (SPEP):
Official Sources
- Albumin Blood Test: MedlinePlus Medical TestMedlinePlus
Research & Guidelines
- PubMed: Albumin (SPEP) Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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