Alpha-1 Globulin
- Sample Type
- Standard
- Fasting
- No
- Unit
- g/dL
Alpha-1 Globulin is a fraction of serum proteins identified during electrophoresis. It primarily consists of Alpha-1 Antitrypsin (AAT), an acute-phase reactant. This fraction increases during systemic inflammation, infection, or trauma. A decrease in this fraction is a critical screening marker for Alpha-1 Antitrypsin Deficiency, which can lead to early-onset emphysema and liver cirrhosis.
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Check Your Result
Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
Because Alpha-1 globulin is an acute-phase reactant, a 'normal' level might actually mask an underlying deficiency if the patient has concurrent inflammation. Phenotyping or genotyping may be required for a definitive diagnosis if levels are borderline.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Alpha-1 Globulin:
Official Sources
- Alpha-1 Antitrypsin Deficiency - StatPearls - NCBI Bookshelfncbi.nlm.nih.gov
Research & Guidelines
- PubMed: Alpha-1 Globulin Clinical GuidelinesNCBI / PubMed
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
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