Antinuclear Antibody (ANA) Screen
- Sample Type
- Standard
- Fasting
- No
- Unit
- Titer
The ANA Screen is a fundamental screening test for Systemic Autoimmune Rheumatic Diseases (SARD). In an Arthritis Basic Screen, it is used to identify the presence of autoantibodies that attack the body's own cell nuclei. While highly sensitive for Systemic Lupus Erythematosus (SLE) (95-98% sensitivity), it is not specific and can be positive in various conditions like Sjogren's syndrome, scleroderma, or even healthy individuals.
Why Context Matters
A 'false positive' ANA is common, especially in the elderly or during viral infections. Since a positive result can cause significant patient anxiety, a second opinion is often needed to interpret the 'pattern' (e.g., homogeneous, speckled) and to order specific follow-up tests (like Anti-dsDNA or Anti-Smith) to confirm if a true autoimmune disease exists.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Antinuclear Antibody (ANA) Screen:
Official Sources
- Systemic lupus erythematosus: one year in review 2025 - PubMedpubmed.ncbi.nlm.nih.gov
Research & Guidelines
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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