Antinuclear Antibody (ANA) Screen
- Sample Type
- Standard
- Fasting
- No
- Unit
- Titer
The ANA Screen is a fundamental test for detecting autoantibodies that target the nucleus of the host's own cells. In the context of an Autoimmune Hepatitis (AIH) Panel, a positive ANA is one of the hallmark diagnostic criteria for Type 1 AIH. It indicates that the immune system is mounting an attack against liver tissue. The 'Titer' indicates the concentration of these antibodies; higher titers (e.g., 1:160) are more clinically significant than low-level positives.
Why Context Matters
Up to 15% of healthy individuals can have a positive ANA at low titers (1:40 or 1:80). Additionally, ANA can be positive due to chronic viral infections (like Hepatitis C), medications (drug-induced lupus/hepatitis), or other systemic autoimmune conditions (SLE, Sjogren's), requiring careful clinical correlation to confirm AIH.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Antinuclear Antibody (ANA) Screen:
Official Sources
- ANA test - Mayo ClinicMayo Clinic
Research & Guidelines
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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