Liver-Kidney Microsome Type 1 (LKM-1) Antibody
- Sample Type
- Standard
- Fasting
- No
- Unit
- U/mL
The LKM-1 antibody is a hallmark serological marker for Autoimmune Hepatitis (AIH) Type 2. This form of AIH typically affects children and young adults and often presents with more severe clinical features than Type 1. The antibody targets the cytochrome P450 2D6 enzyme. Testing is vital for differentiating autoimmune liver disease from viral hepatitis or drug-induced liver injury.
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Enter your lab result to see where you stand compared to the standard reference range.
Why Context Matters
LKM-1 antibodies can sometimes be found in patients with Chronic Hepatitis C (approx. 5-10%), which complicates the diagnosis. Distinguishing between AIH and Hepatitis C is critical because steroids (the treatment for AIH) can exacerbate viral replication.
Lab ranges are statistical averages, not biological laws. "Normal" for a 20-year-old male isn't normal for a 60-year-old female.
Clinical References
Source-of-truth databases and clinical guidelines for Liver-Kidney Microsome Type 1 (LKM-1) Antibody:
Official Sources
- EASL Clinical Practice Guidelines on the management of autoimmune hepatitis - PubMedpubmed.ncbi.nlm.nih.gov
- EASL Clinical Practice Guidelines: Autoimmune hepatitis - PubMedpubmed.ncbi.nlm.nih.gov
Research & Guidelines
Related Indicators
Medically Reviewed by Dr. Binoy Babu, MBBS
Board Certified Doctor • 10+ Years Clinical Experience
Dr. Babu is a practicing physician dedicated to empowering patients with clear, actionable medical information. He founded 2opi to bridge the gap between complex lab reports and patient understanding, ensuring everyone has access to a reliable second opinion.
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